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In the polymerization in vitro of actin filaments and microtubules from their subunits, what does the "lag phase" correspond to? Nucleation Reaching steady state Nucleotide exchange ATP or GTP hydrolysis Treadmilling

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safiurrehman

Answer:

Nucleation

Explanation:

The first step of formation of new phase, structure or self-assembly is called as Nucleation.

It is mentioned in the book of Molecular Biology of the Cell that whenever, In-vitro polymerization of micro-tubules and actin filament occur the first step is called nucleation. In other words Lag Phase.

Reference: Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell. 4th edition. New York: Garland Science; 2002. The Self-Assembly and Dynamic Structure of Cytoskeletal Filaments.

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