Lowering Bad Cholesterol NAME Which of two widely prescribed drugs Lipitor or Pravachol helps lower "bad cholesterol" more? In an experiment, called the PROVE-IT Study, researchers recruited about 4000 people with heart disease as subiects. These volunteers were randomly assigned to one of two treatment groups: Lipitor or Pravachol. At the end of the study, researchers compared the proportion of subjects in each group who died, had a heart attack, or suffered other serious consequences within two years. For the 2063 subjects using Pravachol, the proportion was 0.263. For the 2099 subjects using Lipitor, the proportion was 0.224.